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IOCB Prague

Iva Pichová Group

Viral and Microbial Proteins
Research Group
Senior
BIO cluster

About our group

The research of our laboratory focuses mainly on functional and structural studies of key proteins from Hepatitis B virus and Mycobacteria spp and their interactions with cellular proteins. We also study proteins from pathogenic yeasts and cooperate with chemical ecologists on insect pheromone biosynthetic enzymes.

Research projects involve protein engineering, protein purification, protein characterization, enzymology, NMR and X-ray protein structure solution, isolation and analysis of complexes of cellular and pathogenic proteins, various molecular biological methods, and electron microscopy analysis. Our close cooperation with organic chemists facilitates multidisciplinary research focused on identification and characterization of enzymes involved in drug metabolism and testing of potential inhibitors.

The group is a member of the Gilead Sciences & IOCB Research Centre, NPU 1 and OPVVV projects.

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Publications

All publications
Cellular Localization of Carbonic Anhydrase Nce103p in Candida albicans and Candida parapsilosis
Jiří Dostál
Romana Hadravová
Martin Hubálek
Olga Heidingsfeld
Iva Pichová
International Journal of Molecular Sciences 21 (3): 850 (2020).
Analysis of nucleotide pools in bacteria using HPLC-MS in HILIC mode
Eva Zborníková
Zdeněk Knejzlík
V. Hauryliuk
Libor Krásný
Dominik Rejman
Talanta 205 : Early View (2019).
Catabolism of 8-oxo-purines is mainly routed via the guanine to xanthine interconversion pathway in Mycobacterium smegmatis
Zdeněk Knejzlík
Klára Herkommerová
Iva Pichová
Tuberculosis 119 (-): Early View (2019).